This review has highlighted that in MIRI, excessive ROS production overwhelms the hearts endogenous defenses, leading to unchecked oxidative damage and severe downstream consequences
PLoS ONE 11 , e0149122 (2016)
For decades, the only remedy science offered was synthetic HGH therapya controversial, prohibitively expensive, and heavily regulated treatment fraught with risks like insulin resistance and organ enlargement
Oxidized forms of metals (Fe 3+ , Cu 2+ ) are quickly restored in the cytosolic environment, fueling the vicious circle
Treatment doses for deficiency are substantially higher, typically involving intramuscular injections of 1,000 g or oral supplementation of 502,000 g daily, depending on the underlying cause and severity